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Literature summary extracted from

  • Canada, K.A.; Iwashita, S.; Shim, H.; Wood, T.K.
    Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation (2002), J. Bacteriol., 184, 344-349 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.13.243 V106A mutation in subunit TomA3, colony turns green. Mutant degrades trichloroethylene, 1,1-dichloroethylene, and trans-dichloroethylene more rapidly than wild-type. Whole cells expressing the mutant synthesize 1-naphthol six times faster than wild-type enzyme Burkholderia cepacia

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.243 Burkholderia cepacia Q9ANX4 and Q9ANX0 and Q9ANX3 and Q8VSV8 and Q9ANX1 and Q8VSV9 Q9ANX4 i.e. subunit tomA1, Q9ANX0 i.e. subunit tomA5, Q9ANX3 i.e. subunit TomA2, Q8VSV8 i.e. subunit TomA3, Q9ANX1 i.e. subunit TomA4, Q8VSV9 i.e. subunit TomA0
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1.14.13.243 Burkholderia cepacia G4 Q9ANX4 and Q9ANX0 and Q9ANX3 and Q8VSV8 and Q9ANX1 and Q8VSV9 Q9ANX4 i.e. subunit tomA1, Q9ANX0 i.e. subunit tomA5, Q9ANX3 i.e. subunit TomA2, Q8VSV8 i.e. subunit TomA3, Q9ANX1 i.e. subunit TomA4, Q8VSV9 i.e. subunit TomA0
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.243 naphthalene + NADH + H+ + O2
-
 Burkholderia cepacia 1-naphthol + NAD+ + H2O
-
 ?
1.14.13.243 naphthalene + NADH + H+ + O2
-
 Burkholderia cepacia G4 1-naphthol + NAD+ + H2O
-
 ?